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Gene Family: IgCAM CXADR-related subfamily

Also known as : "CAR subgroup"

Genes contained within the family: 8

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CLMP CXADR like membrane protein ASAM, FLJ22415, ACAM 11q24.1
CXADR CXADR, Ig-like cell adhesion molecule CAR 21q21.1
ESAM endothelial cell adhesion molecule W117m 11q24.2
GPA33 glycoprotein A33 A33 1q24.1
IGSF11 immunoglobulin superfamily member 11 BT-IgSF, MGC35227, Igsf13, VSIG3, CT119 3q13.32
VSIG1 V-set and immunoglobulin domain containing 1 MGC44287 Xq22.3
VSIG2 V-set and immunoglobulin domain containing 2 CTXL, CTH 11q24.2
VSIG8 V-set and immunoglobulin domain containing 8 1q23.2

Comments

CXADR-related proteins are type I transmembrane proteins containing an N-terminal variable (V-type) and a membrane proximal constant (C2-type) Ig domain in their extracellular region which are implicated in homotypic adhesion. Five paralogous human genes (CXADR, CLMP, GPA33, ESAM and IGSF11) are described in the cited reviews, but further paralogs were added using Ensembl.

Publications

25300131,27871939