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Gene Family: Ig-like cell adhesion molecule family

Also known as : "Immunoglobulin-like cell adhesion molecules", "IgCAM", "Immunoglobulin superfamily cell adhesion molecules", " IgSF CAM"

IgSF CAM: Immunoglobulin superfamily CAMs ( IgSF CAMs ) are a class of cell adhesion molecules. They are either homophilic or heterophilic and bind integrins or different IgSF CAMs. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 92

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ALCAM activated leukocyte cell adhesion molecule CD166, MEMD 3q13.11
BCAM basal cell adhesion molecule (Lutheran blood group) LU CD239 19q13.32
BOC BOC cell adhesion associated, oncogene regulated CDON2 3q13.2
CADM1 cell adhesion molecule 1 TSLC1, IGSF4 NECL2, ST17, BL2, SYNCAM, IGSF4A, Necl-2, SYNCAM1, RA175 11q23.3
CADM2 cell adhesion molecule 2 IGSF4D NECL3, Necl-3, SynCAM2 3p12.1
CADM3 cell adhesion molecule 3 IGSF4B BIgR, FLJ10698, TSLL1, NECL1, SynCAM3, Necl-1 1q23.2
CADM4 cell adhesion molecule 4 IGSF4C TSLL2, Necl-4, SynCAM4 19q13.31
CD2 CD2 molecule SRBC 1p13.1
CD22 CD22 molecule SIGLEC-2, SIGLEC2 19q13.12
CD28 CD28 molecule 2q33.2
CD47 CD47 molecule MER6 IAP, OA3 3q13.12
CD58 CD58 molecule LFA3 1p13.1
CD84 CD84 molecule SLAMF5, hCD84, mCD84 1q23.3
CD96 CD96 molecule TACTILE 3q13.13-q13.2
CD244 CD244 molecule 2B4, NAIL, NKR2B4, Nmrk, SLAMF4 1q23.3
CHL1 cell adhesion molecule L1 like CALL, L1CAM2, FLJ44930, MGC132578 3p26.3
CNTN1 contactin 1 F3, GP135 12q12
CNTN2 contactin 2 TAX, AXT TAG-1, TAX1 1q32.1
CNTN3 contactin 3 PANG BIG-1 3p12.3
CNTN4 contactin 4 BIG-2 3p26.3-p26.2
CNTN5 contactin 5 NB-2, hNB-2 11q22.1
CNTN6 contactin 6 NB-3 3p26.3
CRTAM cytotoxic and regulatory T-cell molecule CD355 11q24.1
DSCAM DS cell adhesion molecule CHD2-42, CHD2-52 21q22.2
DSCAML1 DS cell adhesion molecule like 1 KIAA1132 11q23.3
FGFRL1 fibroblast growth factor receptor like 1 4p16.3
F11R F11 receptor JAM1 PAM-1, JCAM, JAM-1, JAM-A, JAMA, CD321 1q23.3
GP6 glycoprotein VI platelet GPVI 19q13.42
HEPACAM hepatic and glial cell adhesion molecule FLJ25530, hepaCAM, GLIALCAM 11q24.2
ICAM1 intercellular adhesion molecule 1 BB2, CD54 19p13.2
ICAM2 intercellular adhesion molecule 2 CD102 17q23.3
ICAM3 intercellular adhesion molecule 3 CDW50, ICAM-R, CD50 19p13.2
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) LW CD242 19p13.2
ICAM5 intercellular adhesion molecule 5 TLCN TLN 19p13.2
IGSF5 immunoglobulin superfamily member 5 JAM4 21q22.2
IZUMO1 izumo sperm-egg fusion 1 IZUMO, MGC34799, OBF 19q13.33
IZUMO1R IZUMO1 receptor, JUNO FOLR4 Folbp3, JUNO 11q21
JAML junction adhesion molecule like AMICA1 Gm638, AMICA 11q23.3
JAM2 junctional adhesion molecule 2 C21orf43 VE-JAM, JAM-B, JAMB, CD322 21q21.3
JAM3 junctional adhesion molecule 3 JAM-C, JAMC 11q25
LILRB2 leukocyte immunoglobulin like receptor B2 LIR-2, ILT4, MIR-10, LIR2, CD85d, MIR10 19q13.4
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 KIAA1484, SALM2 19q13.2
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 KIAA1246, SALM1 FIGLER2 6p21.2-p21.1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 MGC2656, SALM4, FIGLER1 19q13.13
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 MGC3103, SALM3., FIGLER6 11q13.1
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 C14orf146 FIGLER8, SALM5 14q21.1
LRRC4 leucine rich repeat containing 4 NAG14 7q32.1
LRRC4B leucine rich repeat containing 4B LRIG4 DKFZp761A179, HSM 19q13.33
LRRC4C leucine rich repeat containing 4C KIAA1580, NGL-1 11p12
L1CAM L1 cell adhesion molecule HSAS1, SPG1, HSAS, MASA, MIC5, S10 CD171 Xq28
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 MACAM1 19p13.3
MAG myelin associated glycoprotein GMA SIGLEC4A, SIGLEC-4A, S-MAG 19q13.1
MCAM melanoma cell adhesion molecule MUC18, CD146 11q23.3
MPZ myelin protein zero CMT1, CMT1B HMSNIB, CMT2I, CMT2J 1q23.3
MPZL2 myelin protein zero like 2 EVA1 EVA 11q24
NCAM1 neural cell adhesion molecule 1 NCAM, CD56 11q23.2
NCAM2 neural cell adhesion molecule 2 NCAM21, MGC51008 21q21.1
NECTIN1 nectin cell adhesion molecule 1 HVEC, ED4, PVRL1 PRR, PRR1, PVRR1, SK-12, HIgR, CLPED1, CD111, OFC7 11q23.3
NECTIN2 nectin cell adhesion molecule 2 HVEB, PVRL2 PVRR2, PRR2, CD112 19q13.32
NECTIN3 nectin cell adhesion molecule 3 PVRL3 nectin-3, PPR3, PVRR3, DKFZP566B0846, CDw113, CD113 3q13.13
NECTIN4 nectin cell adhesion molecule 4 PVRL4 nectin-4, PRR4, LNIR 1q23.3
NEO1 neogenin 1 NGN, HsT17534, IGDCC2, NTN1R2 15q24.1
NFASC neurofascin NRCAML, KIAA0756, FLJ46866, NF 1q32.1
NRCAM neuronal cell adhesion molecule KIAA0343, Bravo 7q31.1
PECAM1 platelet and endothelial cell adhesion molecule 1 CD31 17q23.3
PTPRM protein tyrosine phosphatase, receptor type M PTPRL1 RPTPU, hR-PTPu 18p11.23
PVR poliovirus receptor PVS CD155, HVED, Necl-5, NECL5, Tage4 19q13.31
ROBO1 roundabout guidance receptor 1 DUTT1, FLJ21882, SAX3 3p12.3
ROBO2 roundabout guidance receptor 2 KIAA1568 3p12.3
SDK1 sidekick cell adhesion molecule 1 FLJ31425 7p22.2
SIGLECL1 SIGLEC family like 1 C19orf75, SIGLEC23P, SIGLECP7 FLJ40235 19q13.41
SIGLEC1 sialic acid binding Ig like lectin 1 SN SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin 20p13
SIGLEC5 sialic acid binding Ig like lectin 5 CD33L2 OB-BP2, SIGLEC-5, CD170 19q13.41
SIGLEC6 sialic acid binding Ig like lectin 6 CD33L, CD33L1 OB-BP1, SIGLEC-6, CD327 19q13.41
SIGLEC7 sialic acid binding Ig like lectin 7 SIGLEC19P, SIGLECP2 SIGLEC-7, p75/AIRM1, QA79, CD328 19q13.41
SIGLEC8 sialic acid binding Ig like lectin 8 SIGLEC-8, SAF2, SIGLEC8L, MGC59785 19q13.33-q13.41
SIGLEC9 sialic acid binding Ig like lectin 9 CD329 19q13.3-q13.4
SIGLEC10 sialic acid binding Ig like lectin 10 SIGLEC-10, SLG2, PRO940, MGC126774 19q13.41
SIGLEC11 sialic acid binding Ig like lectin 11 19q13.33
SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) SIGLECL1 SLG, S2V, Siglec-XII, Siglec-12, Siglec-L1 19q13.41
SIGLEC14 sialic acid binding Ig like lectin 14 19q13.41
SIGLEC15 sialic acid binding Ig like lectin 15 CD33L3 HsT1361 18q21.1
SIGLEC16 sialic acid binding Ig like lectin 16 (gene/pseudogene) SIGLECP16 Siglec-P16 19q13.33
SIRPA signal regulatory protein alpha PTPNS1 SHPS1, SIRP, MYD-1, BIT, P84, SHPS-1, SIRPalpha, CD172a, SIRPalpha2, MFR, SIRP-ALPHA-1 20p13
SIRPG signal regulatory protein gamma SIRPB2 bA77C3.1, SIRP-B2, SIRPgamma, CD172g 20p13
SLAMF1 signaling lymphocytic activation molecule family member 1 SLAM CD150 1q23.3
SLAMF6 SLAM family member 6 KALI, NTBA, KALIb, Ly108, SF2000, NTB-A, CD352 1q23.2-q23.3
THY1 Thy-1 cell surface antigen CD90 11q23.3
UNC5A unc-5 netrin receptor A KIAA1976, UNC5H1 5q35.2
UNC5B unc-5 netrin receptor B UNC5H2, p53RDL1 10q22.1
UNC5D unc-5 netrin receptor D KIAA1777, Unc5h4 8p12
VCAM1 vascular cell adhesion molecule 1 CD106 1p21.2

Genes contained within subsets


Immunoglobulin-like cell adhesion molecules (IgCAMS), like cadherins, are generally single-span type I transmembrane proteins (Brummendorf & Rathjen 1996, Rougon & Hobert 2003). The IgCAMS represent one of the most ancient and diverse families of cell adhesion proteins. Members of this adhesion protein family have diverse mechanisms of function. Some have homophilic binding specificity; others have heterophilic specificity and interact with other IgCAMs; and some interact with cell surface proteins of different classes, notably the integrins.