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Gene Family: BRISC complex

Also known as : "BRCC36 (BRCC3) isopeptidase complex"

: The BRCC36 isopeptidase complex (BRISC) is a Deubiquitinating enzyme (DUB) that is specific for lysine 63-linked ubiquitin hydrolysis. The BRISC complex regulates the assembly of the mitotic spindle by deubiquitinating the essential spindle assembly factor nuclear mitotic apparatus (NuMA). [Source: Yan et al, 2015]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BABAM1 BRISC and BRCA1 A complex member 1 C19orf62 FLJ20571, HSPC142, NBA1, MERIT40 19p13.11
BRCC3 BRCA1/BRCA2-containing complex subunit 3 CXorf53 C6.1A, BRCC36 Xq28
BABAM2 BRISC and BRCA1 A complex member 2 BRE BRCC45, BRCC4 2p23.2
ABRAXAS2 abraxas 2, BRISC complex subunit FAM175B, KIAA0157 Em:AC068896.4, ABRO1 10q26.13

Publications

19214193,20656689,22974638