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Gene Family: MRN complex

MRN complex: The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex binds avidly to double-strand breaks both in vitro and in vivo and may serve to tether broken ends prior to repair by non-homologous end joining or to initiate resection prior to repair by homologous recombination. The MRN complex also participates in activating the checkpoint kinase ATM in response to DNA damage. Production of short single-strand oligonucleotides by Mre11 endonuclease activity has been implicated in ATM activation by the MRN complex. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MRE11 MRE11 homolog, double strand break repair nuclease MRE11A ATLD 11q21
NBN nibrin NBS, NBS1 ATV, AT-V2, AT-V1 8q21.3
RAD50 RAD50 double strand break repair protein hRad50, RAD50-2 5q31.1

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