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Gene Family: MTOR complex 1

Also known as : "mTORC1", "mammalian target of rapamycin complex 1", "mechanistic target of rapamycin complex 1", "TOR complex 1"

MTORC1: mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrientredox sensor and controls protein synthesis. This complex embodies the classic functions of mTOR, namely as a nutrient/energy/redox sensor and controller of protein synthesis. The activity of this complex is regulated by rapamycin, insulin, growth factors, phosphatidic acid, certain amino acids and their derivatives (e.g., L -leucine and β-hydroxy β-methylbutyric acid ), mechanical stimuli, and oxidative stress. The role of mTORC1 is to activate translation of proteins. In order for cells to grow and proliferate by manufacturing more proteins, the cells must ensure that they have the resources available for protein production. Thus, for protein production, and therefore mTORC1 activation, cells must have adequate energy resources, nutrient availability, oxygen abundance, and proper growth factors in order for mRNA translation to begin. [Source: Wikipedia]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
AKT1S1 AKT1 substrate 1 PRAS40, MGC2865, Lobe 19q13.33
MLST8 MTOR associated protein, LST8 homolog Lst8, Pop3, GBL, GbetaL 16p13.3
MTOR mechanistic target of rapamycin kinase FRAP, FRAP2, FRAP1 RAFT1, RAPT1, FLJ44809 1p36.22
RPTOR regulatory associated protein of MTOR complex 1 KOG1, Mip1, KIAA1303, raptor 17q25.3

Comments

DEPTOR is associated with the mTORC1 complex as an endogenous regulator

Publications

22552098,26937223