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Gene Family: MIS12 kinetochore complex

MIS12 complex: During mitosis, the spindle checkpoint senses kinetochores not properly attached to spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy. The constitutive centromere-associated network (CCAN) at inner kinetochores anchors the KMN network consisting of Knl1, the Mis12 complex (Mis12C), and the Ndc80 complex (Ndc80C) at outer kinetochores. [Source: Kim & Yu, 2015]

Genes contained within the family: 4

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
DSN1 DSN1 homolog, MIS12 kinetochore complex component C20orf172 dJ469A13.2, MIS13, KNL3, hKNL-3 20q11.23
MIS12 MIS12, kinetochore complex component MGC2488, hMIS12, KNTC2AP, MTW1 17p13.2
NSL1 NSL1, MIS12 kinetochore complex component C1orf48 DC8, DKFZP566O1646, MIS14 1q32.3
PMF1 polyamine modulated factor 1 1q22

Publications

26430240,26668330,25601404