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Gene Family: BTG/Tob family

Also known as : "APRO family"

BTG/Tob family: The mammalian BTG/Tob family gene products have anti-proliferative ability and are characterised by a conserved BTG domain. Tob subfamily members have the most extensive C-terminal regions. The BTG domain mediates interactions with the highly similar Caf1a (CNOT7) and Caf1b (CNOT8) catalytic subunits of the Ccr4-Not deadenylase complex. Overexpression of BTG/Tob proteins is associated with the inhibition of G1 to S-phase cell cycle progression and decreased cell proliferation in a variety of cell types. [Source: Li et al, 2015]

Genes contained within the family: 6

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BTG1 BTG anti-proliferation factor 1 APRO2 12q21.33
BTG2 BTG anti-proliferation factor 2 PC3, TIS21, MGC126063, MGC126064, APRO1 1q32.1
BTG3 BTG anti-proliferation factor 3 ANA, tob55, APRO4, ANA/BTG3 21q21.1
BTG4 BTG anti-proliferation factor 4 PC3B, APRO3 11q23.1
TOB1 transducer of ERBB2, 1 TROB1 TOB, TROB, APRO5 17q21.33
TOB2 transducer of ERBB2, 2 TROB2 TOBL, TOB4, bK223H9, APRO5 22q13.2

Publications

25951976,11377414,23236473