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Gene Family: FERM domain containing

Also known as : "Four-point-one, ezrin, radixin, moesin domain containing", "ERM domain containing", "Band 4.1 homologs"

FERM domain: In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin ) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal -associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found. [Source: Wikipedia]

Genes contained within the family: 50

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
EPB41 erythrocyte membrane protein band 4.1 EL1 4.1R 1p35.3
EPB41L1 erythrocyte membrane protein band 4.1 like 1 KIAA0338, 4.1N 20q11.23
EPB41L2 erythrocyte membrane protein band 4.1 like 2 4.1-G 6q23.1-q23.2
EPB41L3 erythrocyte membrane protein band 4.1 like 3 DAL1, KIAA0987, 4.1B 18p11.31
EPB41L4A erythrocyte membrane protein band 4.1 like 4A NBL4 5q22.1-q22.2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B EHM2 9q31.3
EPB41L5 erythrocyte membrane protein band 4.1 like 5 KIAA1548, FLJ12957, BE37, YMO1, YRT 2q14.2
EZR ezrin VIL2 6q25.3
FARP1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 CDEP, PLEKHC2, MGC87400, PPP1R75 13q32.2
FARP2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 KIAA0793, FIR, PLEKHC3, FRG 2q37.3
FERMT1 fermitin family member 1 C20orf42 FLJ20116, URP1, KIND1, UNC112A 20p12.3
FERMT2 fermitin family member 2 PLEKHC1 mig-2, KIND2, UNC112B 14q22.1
FERMT3 fermitin family member 3 URP2, KIND3, MIG2B, MGC10966, MIG-2, UNC112C 11q13.1
FRMD1 FERM domain containing 1 FLJ00181, DKFZp434O0117, FLJ40260, FLJ22615, bA164L23.1 6q27
FRMD3 FERM domain containing 3 EPB41L4O, MGC20553 9q21.32
FRMD4A FERM domain containing 4A FRMD4 FLJ10210, KIAA1294, bA295P9.4 10p13
FRMD4B FERM domain containing 4B KIAA1013, GRSP1 3p14.1
FRMD5 FERM domain containing 5 MGC14161 15q15.3
FRMD6 FERM domain containing 6 C14orf31 MGC17921, willin, EX1 14q22.1
FRMD7 FERM domain containing 7 NYS, NYS1 FLJ43346 Xq26.2
FRMD8 FERM domain containing 8 FLJ90369, FKSG44 11q13.1
FRMPD1 FERM and PDZ domain containing 1 KIAA0967, FRMD2 9p13.2
FRMPD2 FERM and PDZ domain containing 2 PDZD5C, PDZK5C MGC35285 10q11.22
FRMPD3 FERM and PDZ domain containing 3 RP5-1070B1.1, KIAA1817 Xq22.3
FRMPD4 FERM and PDZ domain containing 4 PDZK10, PDZD10 KIAA0316 Xp22.2
JAK1 Janus kinase 1 JAK1B JAK1A, JTK3 1p31.3
JAK2 Janus kinase 2 JTK10 9p24.1
KRIT1 KRIT1, ankyrin repeat containing CCM1 CAM 7q21.2
MSN moesin Xq12
MYLIP myosin regulatory light chain interacting protein MIR, IDOL 6p22.3
MYO7A myosin VIIA USH1B, DFNB2, DFNA11 NSRD2 11q13.5
MYO7B myosin VIIB 2q14.3
MYO10 myosin X KIAA0799 5p15.1
MYO15A myosin XVA DFNB3, MYO15 17p11.2
MYO15B myosin XVB MYO15BP 17q25.1
NF2 neurofibromin 2 merlin, ACN, SCH, BANF 22q12.2
PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 KIAA1200 14q24.1
PLEKHH2 pleckstrin homology, MyTH4 and FERM domain containing H2 KIAA2028, PLEKHH1L 2p21
PLEKHH3 pleckstrin homology, MyTH4 and FERM domain containing H3 FLJ21019 17q21.2
PTK2 protein tyrosine kinase 2 FAK, FADK, FAK1, PPP1R71 8q24.3
PTK2B protein tyrosine kinase 2 beta FAK2 CAKB, PYK2, RAFTK, PTK, CADTK 8p21.2
PTPN3 protein tyrosine phosphatase, non-receptor type 3 PTPH1 9q31
PTPN4 protein tyrosine phosphatase, non-receptor type 4 PTPMEG 2q14.2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 PTP1E, PTP-BAS, PTPL1, PTP-BL 4q21.3
PTPN14 protein tyrosine phosphatase, non-receptor type 14 PEZ 1q32.3-q41
PTPN21 protein tyrosine phosphatase, non-receptor type 21 PTPD1, PTPRL10 14q31
RDX radixin DFNB24 11q23
TLN1 talin 1 TLN ILWEQ 9p13.3
TLN2 talin 2 KIAA0320, ILWEQ 15q22.2
TYK2 tyrosine kinase 2 JTK1 19p13.2