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Gene Family: BCL2 homology region 3 (BH3) only

A subset of : BCL2 family

BH3-only family: The BH3-only subset of the Bcl-2 family of proteins contain only a single BH3-domain. The BH3-only members play a key role in promoting apoptosis. The BH3-only family members are Bim, Bid, BAD and others. Various apoptotic stimuli induce expression and/or activation of specific BH3-only family members, which translocate to the mitochondria and initiate Bax/Bak-dependent apoptosis. [Source: Wikipedia]

Genes contained within the family: 11

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BAD BCL2 associated agonist of cell death BCL2L8, BBC2 11q13.1
BBC3 BCL2 binding component 3 JFY1, PUMA 19q13.32
BCL2L11 BCL2 like 11 BOD, BimL, BimEL, BimS, BIM 2q13
BID BH3 interacting domain death agonist 22q11.21
BIK BCL2 interacting killer NBK 22q13.2
BMF Bcl2 modifying factor FLJ00065 15q15.1
BNIP1 BCL2 interacting protein 1 Nip1, SEC20 5q35.1
BNIP3 BCL2 interacting protein 3 Nip3 10q26.3
RTL10 retrotransposon Gag like 10 C22orf29 FLJ21125, BOP 22q11.21
HRK harakiri, BCL2 interacting protein DP5 12q24.22
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 APR, NOXA 18q21.32

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