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Gene Family: LIM domain containing

A subset of : Zinc fingers

LIM domain: LIM domains are protein structural domains, composed of two contiguous zinc finger domains, separated by a two- amino acid residue hydrophobic linker. They are named after their initial discovery in the proteins L in11, I sl-1 & M ec-3. LIM-domain containing proteins have been shown to play roles in cytoskeletal organisation, organ development and oncogenesis. LIM-domains mediate protein:protein interactions that are critical to cellular processes. LIM domains have highly divergent sequences, apart from certain key residues. The sequence divergence allow a great many different binding sites to be grafted onto the same basic domain. The conserved residues are those involved in zinc binding or the hydrophobic core of the protein. The sequence signature of LIM domains is as follows: - 2-4 -- 13-19 --- 2-4 ----- 2-4 -- 13-20 -C- 2-4 - LIM domain organisation LIM domains frequently occur in multiples, as seen in proteins such as TES, LMO4, and can also be attached to other domains in order to confer a binding or targeting function upon them, such as LIM-kinase. The LIM superclass of genes have been classified into 14 classes: ABLIM, CRP, ENIGMA, EPLIN, LASP, LHX, LMO, LIMK, LMO7, MICAL, PXN, PINCH, TES, and ZYX. Six of these classes (i.e., ABLIM, MICAL, ENIGMA, ZYX, LHX, LM07) originated in the stem lineage of animals, and this expansion is thought to have made a major contribution to the origin of animal multicellularity. LIM domains are also found in various bacterial lineages where they are typically fused to a metallopeptidase domain. Some versions show fusions to an inactive P-loop NTPase at their N-terminus and a single transmembrane helix. These domain fusions suggest that the prokaryotic LIM domains are likely to regulate protein processing at the cell membrane. The domain architectural syntax is remarkable parallel to those of the prokaryotic versions of the B-box zinc finger and the AN1 zinc finger domains. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 53

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
ABLIM1 actin binding LIM protein 1 LIMAB1, ABLIM abLIM, limatin 10q25.3
ABLIM2 actin binding LIM protein family member 2 KIAA1808 4p16.1
ABLIM3 actin binding LIM protein family member 3 KIAA0843 5q32
CRIP1 cysteine rich protein 1 CRIP 14q32.33
CRIP2 cysteine rich protein 2 CRP2, ESP1 14q32.33
CRIP3 cysteine rich protein 3 TLP-A, bA480N24.2, TLP 6p21.1
CSRP1 cysteine and glycine rich protein 1 CYRP CSRP, D1S181E 1q32.1
CSRP2 cysteine and glycine rich protein 2 SmLIM, CRP2, LMO5 12q21.2
CSRP3 cysteine and glycine rich protein 3 CLP, MLP, CMD1M 11p15.1
FBLIM1 filamin binding LIM protein 1 FBLP-1, CAL, migfilin 1p36.21
FHL1 four and a half LIM domains 1 SLIM1, KYO-T, bA535K18.1, FHL1B, XMPMA, FLH1A, MGC111107 Xq26.3
FHL2 four and a half LIM domains 2 SLIM3, DRAL 2q12.2
FHL3 four and a half LIM domains 3 SLIM2 1p34.3
FHL5 four and a half LIM domains 5 FLJ33049, ACT, dJ393D12.2 6q16.1
LASP1 LIM and SH3 protein 1 MLN50, Lasp-1 17q12
LDB3 LIM domain binding 3 CMD1C PDLIM6, KIAA0613, ZASP 10q23.2
LIMA1 LIM domain and actin binding 1 EPLIN 12q13.12
LIMCH1 LIM and calponin homology domains 1 DKFZP686A01247, LIMCH1A, LMO7B 4p13
LIMD2 LIM domain containing 2 MGC10986 17q23.3
LIMK1 LIM domain kinase 1 LIMK 7q11.23
LIMK2 LIM domain kinase 2 22q12.2
LIMS1 LIM zinc finger domain containing 1 PINCH, PINCH1 2q12.3
LIMS3 LIM zinc finger domain containing 3 2q13
LMCD1 LIM and cysteine rich domains 1 3p25.3
LMO1 LIM domain only 1 RBTN1 TTG1, RHOM1 11p15.4
LMO2 LIM domain only 2 RBTNL1 TTG2, RHOM2, RBTN2 11p13
LMO3 LIM domain only 3 RBTNL2 Rhom-3, DAT1 12p12.3
LMO4 LIM domain only 4 1p22.3
LMO7 LIM domain 7 FBXO20 FBX20, KIAA0858 13q22.2
LPXN leupaxin LDPL 11q12.1
MICALL1 MICAL like 1 MIRAB13, KIAA1668, MICAL-L1 22q13.1
MICALL2 MICAL like 2 MGC46023, FLJ23471, MICAL-L2, JRAB 7p22.3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 NICAL MICAL, FLJ11937, DKFZp434B1517, FLJ21739 6q21
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 KIAA0750 11p15.3
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 KIAA0819 22q11.21
NEBL nebulette LASP2, LNEBL 10p12.31
NRAP nebulin related anchoring protein 10q25.3
PDLIM1 PDZ and LIM domain 1 CLIM1 CLP-36, hCLIM1, CLP36 10q23.33
PDLIM2 PDZ and LIM domain 2 8p21.3
PDLIM3 PDZ and LIM domain 3 ALP 4q35.1
PDLIM4 PDZ and LIM domain 4 RIL 5q31.1
PDLIM5 PDZ and LIM domain 5 LIM, Enh 4q22.3
PDLIM7 PDZ and LIM domain 7 ENIGMA 5q35.3
PRICKLE1 prickle planar cell polarity protein 1 FLJ31937, EPM1B, RILP 12q12
PRICKLE2 prickle planar cell polarity protein 2 DKFZp686D143 3p14.1
PRICKLE3 prickle planar cell polarity protein 3 LMO6 Xp11.23
PRICKLE4 prickle planar cell polarity protein 4 C6orf49 OEBT, DKFZp761H221 6p21.1
PXN paxillin 12q24.23
SCEL sciellin FLJ21667, MGC22531 13q22.3
TES testin LIM domain protein DKFZP586B2022, TESS-2, TESTIN 7q31.2
TGFB1I1 transforming growth factor beta 1 induced transcript 1 Hic-5, TSC-5, ARA55, HIC-5 16p11.2
XIRP2 xin actin binding repeat containing 2 CMYA3 2q24.3
ZNF185 zinc finger protein 185 with LIM domain SCELL Xq28

Genes contained within subsets