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Gene Family: Sodium voltage-gated channel alpha subunits

Voltage-gated sodium channels: Sodium channels are voltage-gated sodium-selective ion channels present in the membrane of most excitable cells. Sodium channels comprise of one pore-forming α subunit, which may be associated with either one or two beta subunits. Alpha-subunits consist of four homologous domains (I–IV), each containing six transmembrane segments (S1–S6) and a pore-forming loop. The positively charged fourth transmembrane segment (S4) acts as a voltage sensor and is involved in channel gating. [Source: IUPHAR ]

Genes contained within the family: 9

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
SCN1A sodium voltage-gated channel alpha subunit 1 SCN1, FEB3 Nav1.1, GEFSP2, HBSCI, NAC1, SMEI 2q24.3
SCN2A sodium voltage-gated channel alpha subunit 2 SCN2A1, SCN2A2 Nav1.2, HBSCII, HBSCI 2q24.3
SCN3A sodium voltage-gated channel alpha subunit 3 Nav1.3 2q24.3
SCN4A sodium voltage-gated channel alpha subunit 4 HYKPP Nav1.4, HYPP, SkM1 17q23.3
SCN5A sodium voltage-gated channel alpha subunit 5 CMD1E Nav1.5, LQT3, HB1, HBBD, PFHB1, IVF, HB2, HH1, SSS1, CDCD2, CMPD2, ICCD 3p22.2
SCN8A sodium voltage-gated channel alpha subunit 8 MED Nav1.6, NaCh6, PN4, CerIII, CIAT 12q13.13
SCN9A sodium voltage-gated channel alpha subunit 9 Nav1.7, PN1, NE-NA, NENA, ETHA 2q24.3
SCN10A sodium voltage-gated channel alpha subunit 10 Nav1.8, hPN3, SNS, PN3 3p22.2
SCN11A sodium voltage-gated channel alpha subunit 11 SCN12A Nav1.9, NaN, SNS-2 3p22.2