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Gene Family: Glutamate ionotropic receptor NMDA type subunits (GRIN)

Also known as : "Glutamate receptors, ionotropic, N-methyl D-aspartate", "NMDA receptors", "N-methyl-D-aspartate receptors", "NMDARs"

NMDA receptor: The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. It is activated when glutamate and glycine (or D-serine ) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N -methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. [Source: Wikipedia]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GRIN1 glutamate ionotropic receptor NMDA type subunit 1 NMDAR1 GluN1 9q34.3
GRIN2A glutamate ionotropic receptor NMDA type subunit 2A NMDAR2A GluN2A 16p13.2
GRIN2B glutamate ionotropic receptor NMDA type subunit 2B NMDAR2B GluN2B 12p13.1
GRIN2C glutamate ionotropic receptor NMDA type subunit 2C NMDAR2C GluN2C 17q25.1
GRIN2D glutamate ionotropic receptor NMDA type subunit 2D NMDAR2D GluN2D, EB11, NR2D 19q13.33
GRIN3A glutamate ionotropic receptor NMDA type subunit 3A GluN3A 9q31.1
GRIN3B glutamate ionotropic receptor NMDA type subunit 3B GluN3B 19p13.3