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Gene Family: Glutamate ionotropic receptor kainate type subunits (GRIK)

Also known as : "Kainate receptors", "KARs", "Glutamate receptors, ionotropic, kainate"

Kainate receptor: Kainate receptors, or KARs, are ionotropic receptors that respond to the neurotransmitter glutamate. They were first identified as a distinct receptor type through their selective activation by the agonist kainate, a drug first isolated from the red alga Digenea simplex. KARs are less understood than AMPA and NMDA receptors, the other ionotropic glutamate receptors. Postsynaptic kainate receptors are involved in excitatory neurotransmission. Presynaptic kainate receptors have been implicated in inhibitory neurotransmission by modulating release of the inhibitory neurotransmitter GABA through a presynaptic mechanism. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
GRIK1 glutamate ionotropic receptor kainate type subunit 1 GLUR5 GluK1 21q21.3
GRIK2 glutamate ionotropic receptor kainate type subunit 2 GLUR6 GluK2, MRT6 6q16.3
GRIK3 glutamate ionotropic receptor kainate type subunit 3 GluK3, GLUR7 1p34.3
GRIK4 glutamate ionotropic receptor kainate type subunit 4 GRIK GluK4, KA1 11q23.3
GRIK5 glutamate ionotropic receptor kainate type subunit 5 GRIK2 GluK5, KA2 19q13.2