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Gene Family: Mannosidases alpha class 2 (MAN2)

Also known as : "Glycoside Hydrolase Family 38", "Class II alpha-mannosidases", "Class 2 alpha-mannosidases"

Class II alpha-mannosidases: Glycoside hydrolases of family 38 are Class II α-mannosidases. They range in breadth of specificity from the Golgi α-mannosidase (2A1), which has a dual specificity for α-1,6 and α-1,3-linked mannoses, to the lysosomal mannosidases, which have either broad (2B1 cleaves α1,2, α1,3 and α1,6 linkages) or narrow specificities (2B2 is specific for α-1,6). There have been GH38 mannosidases identified in a number of different localizations, classed into subfamilies with different substrate specificities and biochemical properties, and, presumably, different physiological roles. The Golgi enzyme is identified as 2A1 (Class 2, A for Golgi, enzyme 1). Lysosomal GH38 mannosidases are indicated by 'B' (2B1, 2B2) and those likely existing in the cytoplasm by 'C'. [Source: CAZypedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MAN2A1 mannosidase alpha class 2A member 1 MANA2 GOLIM7 5q21.3
MAN2A2 mannosidase alpha class 2A member 2 MANA2X, HsT19662 15q25
MAN2B1 mannosidase alpha class 2B member 1 MANB LAMAN 19p13.13
MAN2B2 mannosidase alpha class 2B member 2 KIAA0935 4p16.1
MAN2C1 mannosidase alpha class 2C member 1 MANA1, MANA 15q24.2