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Gene Family: EPH receptors (EPH)

Also known as : "Ephrin receptors"

Ephrin receptor: Ephrin receptors (Ephs) are a group of receptors that are activated in response to binding ephrin. Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Ephs and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Ephephrin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer. [Source: Wikipedia]

Genes contained within the family: 14

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
EPHA1 EPH receptor A1 EPHT, EPHT1 EPH 7q34-q35
EPHA2 EPH receptor A2 ECK 1p36.13
EPHA3 EPH receptor A3 ETK, ETK1, TYRO4 HEK, HEK4 3p11.1
EPHA4 EPH receptor A4 TYRO1 Hek8 2q36.1
EPHA5 EPH receptor A5 Hek7, TYRO4, CEK7, EHK1 4q13.1-q13.2
EPHA6 EPH receptor A6 FLJ35246 3q11.2
EPHA7 EPH receptor A7 Hek11 6q16.1
EPHA8 EPH receptor A8 EEK Hek3 1p36.12
EPHA10 EPH receptor A10 FLJ16103, FLJ33655 1p34.3
EPHB1 EPH receptor B1 EPHT2 Hek6 3q22.2
EPHB2 EPH receptor B2 DRT, ERK, EPHT3 Hek5, Tyro5 1p36.12
EPHB3 EPH receptor B3 ETK2 Hek2, Tyro6 3q27.1
EPHB4 EPH receptor B4 HTK Tyro11 7q22.1
EPHB6 EPH receptor B6 HEP 7q34