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Gene Family: MADS box family

Also known as : "MCM1, AGAMOUS, DEFICIENS, and SRF box transcription factor family", "MADS box transcription factors"

MADS-box: The MADS box is a conserved sequence motif found in genes which comprise the MADS-box gene family. The MADS box encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC 6 GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box reported by various researchers varies somewhat, but typical lengths are in the range of 168 to 180 base pairs, i.e. the encoded MADS domain has a length of 56 to 60 amino acids. There is evidence that the MADS domain evolved from a sequence stretch of a type II topoisomerase in a common ancestor of all extant eukaryotes. [Source: Wikipedia]

Genes contained within the family: 5

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
MEF2A myocyte enhancer factor 2A RSRFC4, RSRFC9 15q26.3
MEF2B myocyte enhancer factor 2B RSRFR2 19p13.11
MEF2C myocyte enhancer factor 2C 5q14.3
MEF2D myocyte enhancer factor 2D 1q22
SRF serum response factor MCM1 6p21.1

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