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Gene Family: Glucose 6-phosphatases, catalytic (G6PC)

Also known as : "G6Pases"
A subset of : Sugar phosphatases

Glucose 6-phosphatase: Glucose 6-phosphatase ( EC 3.1.3.9, G6Pase) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins. This catalysis completes the final step in gluconeogenesis and glycogenolysis and therefore plays a key role in the homeostatic regulation of blood glucose levels. G6Pase is a complex of multiple component proteins, including transporters for G6P, glucose, and phosphate. The main phosphatase function is performed by the G6Pase catalytic subunit. [Source: Wikipedia]

Genes contained within the family: 3

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
G6PC glucose-6-phosphatase catalytic subunit G6PT GSD1a 17q21.31
G6PC2 glucose-6-phosphatase catalytic subunit 2 IGRP 2q31.1
G6PC3 glucose-6-phosphatase catalytic subunit 3 UGRP 17q21.31