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Gene Family: Mediator complex (MED)

Also known as : "TRAP complex", "DRIP coactivator complex "

Mediator (coactivator) complex: Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered by Roger D. Kornberg, winner of the 2006 Nobel Prize in Chemistry. It is also referred to in scientific literature as the vitamin D receptor interacting protein ( DRIP ) coactivator complex and the thyroid hormone receptor-associated proteins ( TRAP ). The mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast. It works in the same manner in mammals. The human Mediator complex has 31+ subunits and is 1.2 MDa in size. Its large surface area provides great potential for protein–protein interaction, even though its sequences do not contain many predicted functional domains. Mediator has been shown to associate with general transcription factors, as well as RNA polymerase II, and is essential for activator-dependent transcription. It has also been demonstrated that the Mediator complex is involved in activator-independent transcription, implying that it may provide a fundamental control of the formation of the initiation complex. Mediator functions as a coactivator and binds to the C-terminal domain of RNA polymerase II holoenzyme, acting as a bridge between this enzyme and transcription factors. [Source: Wikipedia]

Genes contained within the family: 33

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
CCNC cyclin C CycC 6q16.2
CDK8 cyclin dependent kinase 8 K35 13q12.13
CDK19 cyclin dependent kinase 19 CDK11, CDC2L6 KIAA1028, bA346C16.3 6q21
MED1 mediator complex subunit 1 TRIP2, PPARGBP, PPARBP PBP, TRAP220, RB18A, DRIP230, CRSP200, CRSP1 17q12
MED29 mediator complex subunit 29 IXL MED2, DKFZp434H247 19q13.2
MED27 mediator complex subunit 27 CRSP8 TRAP37, CRSP34, MED3 9q34.13
MED4 mediator complex subunit 4 VDRIP HSPC126, DRIP36, TRAP36 13q14.2
MED24 mediator complex subunit 24 THRAP4, CRSP4 MED5, DRIP100, TRAP100, CRSP100, KIAA0130 17q21.1
MED6 mediator complex subunit 6 NY-REN-28 14q24.2
MED7 mediator complex subunit 7 CRSP9 CRSP33 5q33.3
MED8 mediator complex subunit 8 MGC17544, MGC19641, ARC32 1p34.2
MED9 mediator complex subunit 9 FLJ10193, MED25 17p11.2
MED10 mediator complex subunit 10 TRG20, L6, MGC5309, NUT2 5p15.31
MED11 mediator complex subunit 11 HSPC296, MGC88387 17p13.2
MED12 mediator complex subunit 12 TNRC11, FGS1 CAGH45, HOPA, OPA1, TRAP230, KIAA0192, OKS Xq13.1
MED12L mediator complex subunit 12 like KIAA1635, TNRC11L, TRALPUSH, TRALP 3q25.1
MED13 mediator complex subunit 13 THRAP1 KIAA0593, TRAP240 17q23.2
MED13L mediator complex subunit 13 like THRAP2 KIAA1025, TRAP240L 12q24.21
MED14 mediator complex subunit 14 CXorf4, CRSP2 EXLM1, CRSP150, TRAP170, RGR1, CSRP Xp11.4
MED15 mediator complex subunit 15 TNRC7, PCQAP TIG-1, CAG7A, Arc105 22q11.21
MED16 mediator complex subunit 16 THRAP5 DRIP92, TRAP95 19p13.3
MED17 mediator complex subunit 17 CRSP6 CRSP77, TRAP80, DRIP80, SRB4 11q21
MED18 mediator complex subunit 18 FLJ20045, p28b, SRB5 1p35.3
MED19 mediator complex subunit 19 LCMR1 11q12.1
MED20 mediator complex subunit 20 TRFP DKFZp586D2223, PRO0213, SRB2 6p21.1
MED21 mediator complex subunit 21 SURB7 SRB7 12p12
MED22 mediator complex subunit 22 SURF5 Med24, SRB6 9q34.2
MED23 mediator complex subunit 23 CRSP3 CRSP130, DRIP130, Sur2 6q23.2
MED25 mediator complex subunit 25 ARC92, ACID1, TCBAP0758, DKFZp434K0512 19q13.3
MED26 mediator complex subunit 26 CRSP7 CRSP70 19p13.11
MED28 mediator complex subunit 28 EG1, DKFZP434N185, magicin 4p15.32
MED30 mediator complex subunit 30 THRAP6 TRAP25 8q24.11
MED31 mediator complex subunit 31 CGI-125, Soh1 17p13.1

Comments

Some papers include THRAP3 as a subunit of the Mediator complex.

Publications

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