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Gene Family: BCL2 family (BCL2)

Bcl-2 family: Apoptosis regulator Bcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro- apoptotic ( Bax, BAD, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. [Source: Wikipedia]

Family contains the following subsets

Genes contained within the family: 14

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
BCL2 BCL2, apoptosis regulator Bcl-2, PPP1R50 18q21.33
BCL2L1 BCL2 like 1 BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52 20q11.21
BCL2L2 BCL2 like 2 KIAA0271, BCL-W, PPP1R51 14q11.2
MCL1 MCL1, BCL2 family apoptosis regulator Mcl-1, BCL2L3 1q21.2
BAX BCL2 associated X, apoptosis regulator BCL2L4 19q13.33
BCL2A1 BCL2 related protein A1 HBPA1 ACC1, BFL1, ACC-2, BCL2L5, GRS, ACC2, ACC-1 15q25.1
BAK1 BCL2 antagonist/killer 1 CDN1 BAK, BCL2L7 6p21.31
BOK BOK, BCL2 family apoptosis regulator MGC4631, BOKL, BCL2L9 2q37.3
BCL2L10 BCL2 like 10 Diva, Boo, BCL-B 15q21.2
BCL2L12 BCL2 like 12 19q13.33
BCL2L13 BCL2 like 13 MIL1, BCL-RAMBO 22q11.21
BCL2L14 BCL2 like 14 BCLG, BCL-G 12p13.2
BCL2L15 BCL2 like 15 C1orf178 Bfk, FLJ22588 1p13.2
BNIP2 BCL2 interacting protein 2 Nip2, BNIP-2 15q22.2

Genes contained within subsets