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Gene Family: 14-3-3 phospho-serine/phospho-threonine binding proteins (YWHA)

Also known as : "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation proteins"

14-3-3 proteins: 14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE -cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis by Moore and Perez (1967). Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. [Source: Wikipedia]

Genes contained within the family: 7

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta YWHAA 20q13.12
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon FLJ45465 17p13.3
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma PPP1R170 7q11.23
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta YWHA1 22q12.3
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta HS1, 14-3-3 2p25.1
SFN stratifin YWHAS 1p36.11
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta YWHAD KCIP-1, 14-3-3-zeta 8q22.3