Skip to Navigation

Gene Family: X-linked mental retardation (MRX)

Also known as : "X-linked intellectual disability", "XLMR"

X-linked intellectual disability: X-linked intellectual disability (previously known as X-linked mental retardation) refers to forms of intellectual disability which are specifically associated with X-linked recessive inheritance. As with most X-linked disorders, males are more heavily affected than females. Females with one affected X chromosome and one normal X chromosome tend to have milder symptoms. [Source: Wikipedia]

Genes contained within the family: 88

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PRS Prieto X-linked mental retardation syndrome MRXS2 Xp21-p11
MCS Miles-Carpenter X-linked mental retardation syndrome MRXS4 Xq13-q22
HDAC8 histone deacetylase 8 WTS, MRXS6, HDACL1 RPD3 Xq13.1
MRXS7 mental retardation, X-linked, syndromic 7 Xp11.3-q22.1
RENS2 Renpenning syndrome 2 MRXS9 Xq12-q21.31
HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 MRXS10, HADH2 ERAB, MHBD, 17b-HSD10, ABAD, SDR5C1, MRPP2, CAMR Xp11.22
MRXS11 mental retardation, X-linked, syndromic 11 SMRXS Xq26-q27
IQSEC2 IQ motif and Sec7 domain 2 MRX18, MRX78, MRX1 KIAA0522 Xp11.22
PQBP1 polyglutamine binding protein 1 MRX2, SHS, MRXS3, RENS1, MRXS8, MRX55 Xp11.23
HCFC1 host cell factor C1 HFC1, MRX3 HCF-1, HCF1, CFF, VCAF, MGC70925, PPP1R89 Xq28
MRX4 mental retardation, X-linked 4 Xp11.22-q21.3
MRX5 mental retardation, X-linked 5 Xp11.4-q21.2
MRX6 mental retardation, X-linked 6 (Okinawa type) Xq27
MRX7 mental retardation, X-linked 7 Xp11.23-q12
MRX8 mental retardation, X-linked 8 Xq21
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) MRX44, MRX9 JM23, CDLIV, SPB1, TRM7, TRMT7 Xp11.23
IL1RAPL1 interleukin 1 receptor accessory protein like 1 MRX34, IL1RAPL, MRX10, MRX21 OPHN4, TIGIRR-2, IL1R8 Xp21.3-p21.2
MRX11 mental retardation, X-linked 11 Xp21.3-p11.22
THOC2 THO complex 2 MRX12, CXorf3, MRX35 THO2, dJ506G2.1 Xq25
KDM5C lysine demethylase 5C SMCX, MRX13, JARID1C DXS1272E, XE169 Xp11.22
MRX14 mental retardation, X-linked 14 Xp11.3-q13.2
MRX15 mental retardation, X-linked 15 Xp21.1-p11.22
MECP2 methyl-CpG binding protein 2 RTT, MRX79, MRX16 Xq28
MRX17 mental retardation, X-linked 17 Xp11.22
RPS6KA3 ribosomal protein S6 kinase A3 MRX19, CLS RSK, RSK2, HU-3 Xp22.12
MRX20 mental retardation, X-linked 20 Xp11-q21
SLC16A2 solute carrier family 16 member 2 MRX22, DXS128, AHDS XPCT, MCT8, MCT7 Xq13.2
MRX23 mental retardation, X-linked 23 Xq23-q24
MRX24 mental retardation, X-linked 24 Xp22.3-p22.2
MRX25 mental retardation, X-linked 25 Xq28
MRX26 mental retardation, X-linked 26 Xp11.3-q21.33
MRX27 mental retardation, X-linked 27 Xq24-q26
MRX28 mental retardation, X-linked 28 Xq28
ARX aristaless related homeobox MRX87, MRX38, MRX43, MRX76, MRX29, MRX54, PRTS, MRX36, MRX32, MRX33, MRXS1 ISSX, CT121, EIEE1 Xp21.3
PAK3 p21 (RAC1) activated kinase 3 MRX47, MRX30 hPAK3, bPAK Xq23
MRX31 mental retardation, X-linked 31 Xp11.22
MRX37 mental retardation, X-linked 37 Xp22.32-p22.31
MRX39 mental retardation, X-linked 39 X
MRX40 mental retardation, X-linked 40 Xq21.1
GDI1 GDP dissociation inhibitor 1 MRX48, GDIL, MRX41 RABGDIA, XAP-4, OPHN2, FLJ41411 Xq28
MRX42 mental retardation, X-linked 42 X
ZNF81 zinc finger protein 81 MRX45 HFZ20 Xp11.23
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 MRX46 alphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2 Xq26.3
MRX49 mental retardation, X-linked 49 Xp22.3-p22.2
MRX50 mental retardation, X-linked 50 Xp11.3-p11.21
MRX51 mental retardation, X-linked 51 Xp11.3-p11.23
ATRX ATRX, chromatin remodeler JMS, MRX52, RAD54 XH2, XNP Xq21.1
MRX53 mental retardation, X-linked 53 Xq22.2-q24
MRX56 mental retardation, X-linked 56 X
MRX57 mental retardation, X-linked 57 X
TSPAN7 tetraspanin 7 TM4SF2, MRX58, MXS1 DXS1692E, TALLA-1, A15, CD231 Xp11.4
AP1S2 adaptor related protein complex 1 sigma 2 subunit MRX59, PGS, MRXS5 SIGMA1B Xp22.2
OPHN1 oligophrenin 1 MRX60 OPN1, ARHGAP41 Xq12
MRX61 mental retardation, X-linked 61 Xq13.1-q25
UPF3B UPF3B, regulator of nonsense mediated mRNA decay UPF3BP2, MRX62, UPF3BP3, UPF3BP1 RENT3B, UPF3X, HUPF3B Xq24
ACSL4 acyl-CoA synthetase long chain family member 4 MRX68, FACL4, MRX63 ACS4, LACS4 Xq23
MRX64 mental retardation, X-linked 64 Xq28
MRX65 mental retardation, X-linked 65 Xp11.23-q21.32
MRX66 mental retardation, X-linked 66 Xq21.33-q23
MRX67 mental retardation, X-linked 67 Xq13.1-q21.31
MRX69 mental retardation, X-linked 69 Xp11.21-q22.1
MRX70 mental retardation, X-linked 70 Xq23-q25
MRX71 mental retardation, X-linked 71 Xq24-q27
RAB39B RAB39B, member RAS oncogene family MRX72 Xq28
MRX73 mental retardation, X-linked 73 Xp22.2
EFHC2 EF-hand domain containing 2 MRX74 FLJ22843 Xp11.3
MRX75 mental retardation, X-linked 75 Xq24-q26
MRX77 mental retardation, X-linked 77 Xq12-q21.33
MRX80 mental retardation, X-linked 80 Xq22-q24
MRX81 mental retardation, X-linked 81 Xp11.2-q12
MRX82 mental retardation, X-linked 82 Xq24-q25
MRX84 mental retardation, X-linked 84 Xp11.3-q22.3
DMD dystrophin MRX85 BMD, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 Xp21.2-p21.1
MRX86 mental retardation, X-linked 86 Xp11.3-q13.1
AGTR2 angiotensin II receptor type 2 MRX88, AT2 Xq23
ZNF41 zinc finger protein 41 MRX89, MGC8941 Xp11.3
DLG3 discs large MAGUK scaffold protein 3 KIAA1232, MRX90, SAP102, SAP-102, NE-Dlg, NEDLG, PPP1R82 Xq13.1
ZDHHC15 zinc finger DHHC-type containing 15 DHHC15, MRX91, FLJ31812 Xq13.3
ZNF674 zinc finger protein 674 MRX92 ZNF673B Xp11.3
BRWD3 bromodomain and WD repeat domain containing 3 FLJ38568, MRX93 Xq21.1
GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GLUR3 MRX94, GLURC, GluA3 Xq25
MAGT1 magnesium transporter 1 DKFZp564K142, OST3B, IAP, MRX95 Xq21.1
SYP synaptophysin MRX96 Xp11.23
ZNF711 zinc finger protein 711 ZNF6 MRX97, Zfp711, CMPX1, dJ75N13.1, ZNF5, ZNF4 Xq21.1
NEXMIF neurite extension and migration factor KIAA2022 XPN, KIDLIA, MRX98 Xq13.3
USP9X ubiquitin specific peptidase 9, X-linked DFFRX, MRX99, FAF Xp11.4
KIF4A kinesin family member 4A MRX100, HSA271784, FLJ12655, KIF4, KIF4-G1, FLJ12530, FLJ20631, FLJ14204 Xq13.1
MID2 midline 2 RNF60, MRX101, FXY2, TRIM1 Xq22.3

Comments

This gene family lists all genes that have either an MRX# approved symbol or an MRX# synonym. It will not contain genes known to be associated with X-linked mental retardation if they have no MRX# synonym.