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Gene Family: X-linked mental retardation (MRX)

Also known as : "X-linked intellectual disability", "XLMR"

X-linked intellectual disability: X-linked intellectual disability (previously known as X-linked mental retardation) refers to forms of intellectual disability which are specifically associated with X-linked recessive inheritance. As with most X-linked disorders, males are more heavily affected than females. Females with one affected X chromosome and one normal X chromosome tend to have milder symptoms. [Source: Wikipedia]

Genes contained within the family: 88

Approved Symbol Approved Name Previous Symbols Synonyms Chromosome
PRS Prieto X-linked mental retardation syndrome MRXS2 Xp21-p11
MCS Miles-Carpenter X-linked mental retardation syndrome MRXS4 Xq13-q22
HDAC8 histone deacetylase 8 WTS, MRXS6, HDACL1 RPD3 Xq13.1
MRXS7 mental retardation, X-linked, syndromic 7 Xp11.3-q22.1
RENS2 Renpenning syndrome 2 MRXS9 Xq12-q21.31
HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 MRXS10, HADH2 ERAB, MHBD, 17b-HSD10, ABAD, SDR5C1, MRPP2, CAMR Xp11.22
MRXS11 mental retardation, X-linked, syndromic 11 SMRXS Xq26-q27
IQSEC2 IQ motif and Sec7 domain 2 MRX18, MRX78, MRX1 KIAA0522 Xp11.22
PQBP1 polyglutamine binding protein 1 MRX2, SHS, MRXS3, RENS1, MRXS8, MRX55 Xp11.23
HCFC1 host cell factor C1 HFC1, MRX3 HCF-1, HCF1, CFF, VCAF, MGC70925, PPP1R89 Xq28
MRX4 mental retardation, X-linked 4 Xp11.22-q21.3
MRX5 mental retardation, X-linked 5 Xp11.4-q21.2
MRX6 mental retardation, X-linked 6 (Okinawa type) Xq27
MRX7 mental retardation, X-linked 7 Xp11.23-q12
MRX8 mental retardation, X-linked 8 Xq21
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) MRX44, MRX9 JM23, CDLIV, SPB1, TRM7, TRMT7 Xp11.23
IL1RAPL1 interleukin 1 receptor accessory protein like 1 MRX34, IL1RAPL, MRX10, MRX21 OPHN4, TIGIRR-2, IL1R8 Xp21.3-p21.2
MRX11 mental retardation, X-linked 11 Xp21.3-p11.22
THOC2 THO complex 2 MRX12, CXorf3, MRX35 THO2, dJ506G2.1 Xq25
KDM5C lysine demethylase 5C SMCX, MRX13, JARID1C DXS1272E, XE169 Xp11.22
MRX14 mental retardation, X-linked 14 Xp11.3-q13.2
MRX15 mental retardation, X-linked 15 Xp21.1-p11.22
MECP2 methyl-CpG binding protein 2 RTT, MRX79, MRX16 Xq28
MRX17 mental retardation, X-linked 17 Xp11.22
RPS6KA3 ribosomal protein S6 kinase A3 MRX19, CLS RSK, RSK2, HU-3 Xp22.12
MRX20 mental retardation, X-linked 20 Xp11-q21
SLC16A2 solute carrier family 16 member 2 MRX22, DXS128, AHDS XPCT, MCT8, MCT7 Xq13.2
MRX23 mental retardation, X-linked 23 Xq23-q24
MRX24 mental retardation, X-linked 24 Xp22.3-p22.2
MRX25 mental retardation, X-linked 25 Xq28
MRX26 mental retardation, X-linked 26 Xp11.3-q21.33
MRX27 mental retardation, X-linked 27 Xq24-q26
MRX28 mental retardation, X-linked 28 Xq28
ARX aristaless related homeobox MRX87, MRX38, MRX43, MRX76, MRX29, MRX54, PRTS, MRX36, MRX32, MRX33, MRXS1 ISSX, CT121, EIEE1 Xp21.3
PAK3 p21 (RAC1) activated kinase 3 MRX47, MRX30 hPAK3, bPAK Xq23
MRX31 mental retardation, X-linked 31 Xp11.22
MRX37 mental retardation, X-linked 37 Xp22.32-p22.31
MRX39 mental retardation, X-linked 39 X
MRX40 mental retardation, X-linked 40 Xq21.1
GDI1 GDP dissociation inhibitor 1 MRX48, GDIL, MRX41 RABGDIA, XAP-4, OPHN2, FLJ41411 Xq28
MRX42 mental retardation, X-linked 42 X
ZNF81 zinc finger protein 81 MRX45 HFZ20 Xp11.23
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 MRX46 alphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2 Xq26.3
MRX49 mental retardation, X-linked 49 Xp22.3-p22.2
MRX50 mental retardation, X-linked 50 Xp11.3-p11.21
MRX51 mental retardation, X-linked 51 Xp11.3-p11.23
ATRX ATRX, chromatin remodeler JMS, MRX52, RAD54 XH2, XNP Xq21.1
MRX53 mental retardation, X-linked 53 Xq22.2-q24
MRX56 mental retardation, X-linked 56 X
MRX57 mental retardation, X-linked 57 X
TSPAN7 tetraspanin 7 TM4SF2, MRX58, MXS1 DXS1692E, TALLA-1, A15, CD231 Xp11.4
AP1S2 adaptor related protein complex 1 sigma 2 subunit MRX59, PGS, MRXS5 SIGMA1B Xp22.2
OPHN1 oligophrenin 1 MRX60 OPN1, ARHGAP41 Xq12
MRX61 mental retardation, X-linked 61 Xq13.1-q25
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) UPF3BP2, MRX62, UPF3BP3, UPF3BP1 RENT3B, UPF3X, HUPF3B Xq24
ACSL4 acyl-CoA synthetase long-chain family member 4 MRX68, FACL4, MRX63 ACS4, LACS4 Xq23
MRX64 mental retardation, X-linked 64 Xq28
MRX65 mental retardation, X-linked 65 Xp11.23-q21.32
MRX66 mental retardation, X-linked 66 Xq21.33-q23
MRX67 mental retardation, X-linked 67 Xq13.1-q21.31
MRX69 mental retardation, X-linked 69 Xp11.21-q22.1
MRX70 mental retardation, X-linked 70 Xq23-q25
MRX71 mental retardation, X-linked 71 Xq24-q27
RAB39B RAB39B, member RAS oncogene family MRX72 Xq28
MRX73 mental retardation, X-linked 73 Xp22.2
EFHC2 EF-hand domain containing 2 MRX74 FLJ22843 Xp11.3
MRX75 mental retardation, X-linked 75 Xq24-q26
MRX77 mental retardation, X-linked 77 Xq12-q21.33
MRX80 mental retardation, X-linked 80 Xq22-q24
MRX81 mental retardation, X-linked 81 Xp11.2-q12
MRX82 mental retardation, X-linked 82 Xq24-q25
MRX84 mental retardation, X-linked 84 Xp11.3-q22.3
DMD dystrophin MRX85 BMD, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272 Xp21.2-p21.1
MRX86 mental retardation, X-linked 86 Xp11.3-q13.1
AGTR2 angiotensin II receptor type 2 MRX88, AT2 Xq23
ZNF41 zinc finger protein 41 MRX89, MGC8941 Xp11.3
DLG3 discs large MAGUK scaffold protein 3 KIAA1232, MRX90, SAP102, SAP-102, NE-Dlg, NEDLG, PPP1R82 Xq13.1
ZDHHC15 zinc finger DHHC-type containing 15 DHHC15, MRX91, FLJ31812 Xq13.3
ZNF674 zinc finger protein 674 MRX92 ZNF673B Xp11.3
BRWD3 bromodomain and WD repeat domain containing 3 FLJ38568, MRX93 Xq21.1
GRIA3 glutamate ionotropic receptor AMPA type subunit 3 GLUR3 MRX94, GLURC, GluA3 Xq25
MAGT1 magnesium transporter 1 DKFZp564K142, OST3B, IAP, MRX95 Xq21.1
SYP synaptophysin MRX96 Xp11.23
ZNF711 zinc finger protein 711 ZNF6 MRX97, Zfp711, CMPX1, dJ75N13.1, ZNF5, ZNF4 Xq21.1
KIAA2022 KIAA2022 XPN, KIDLIA, MRX98 Xq13.3
USP9X ubiquitin specific peptidase 9, X-linked DFFRX, MRX99, FAF Xp11.4
KIF4A kinesin family member 4A MRX100, HSA271784, FLJ12655, KIF4, KIF4-G1, FLJ12530, FLJ20631, FLJ14204 Xq13.1
MID2 midline 2 RNF60, MRX101, FXY2, TRIM1 Xq22.3

Comments

This gene family lists all genes that have either an MRX# approved symbol or an MRX# synonym. It will not contain genes known to be associated with X-linked mental retardation if they have no MRX# synonym.